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Benzbromarone
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API and Intermediates
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Product Intro
Benzbromarone,a non-competitive inhibitor of xanthine oxidase，is apotent uricosuric drug used in the treatment of gout.
Benzbromarone is a benzofuran derivative chemically related to amiodarone. It increases uric acid excretion by non-specificallyinhibiting its tubular reabsorption.
lt is used in patients with venous disorders to prevent,retard,or reverse varicose degenerative changes in the vessel wall.
Benzbromarone causes diarrhea (3-4% of patients), urate and oxalate stones,urinary sand,renal colic，and allergy in a small number of patients.Liver damage, which reverses after withdrawal, has been described (SEDA-18,108).Function
Benzbromarone plays an anti-gout role mainly by inhibiting the reabsorption of uric acid by renal proximal convoluted tubules and reducing the excessive uric acid concentration in plasma. It not only relieves pain, reduces redness and swelling, but also dissipates gout nodules.
Application
1.Benzbromarone is a uricosuric agent used in the treatment of gout and hyperuricemia. Studies show that use of Benzbromarone results in less complications than other uricosuric agent such as Allopurinol.
2.Coronarodilatator;Uric acid transport inhibitor
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