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3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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API and Intermediates
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Product Intro
Ibotinib intermediate n-2 is an organic synthesis intermediate and pharmaceutical intermediate. It can be used in laboratory R & D process and chemical pharmaceutical synthesis process. It is mainly used as ibotinib intermediate of API. Ibrutinib is a Bruton tyrosine kinase (Btk) inhibitor for the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL).
FunctionIbrutinib can combine with Btk, which is necessary for the formation, differentiation, information transmission and survival of B lymphocytes, irreversibly inhibit the activity of BTK and effectively inhibit the proliferation and survival of tumor cells.
ApplicationIbrutinib is an inhibitor of BTK kinase. It can covalently bind with cysteine residues in the active center of BTK, so as to inhibit the activity of B cells. It has a significant effect on B-cell lymphoma, especially for patients with a variety of advanced lymphomas that are difficult to relapse.
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