Dutasteride and Intermediates
Dutasteride is a new 5 α It is a dual inhibitor of reductase, which can inhibit 5 α Reductase-1 can also inhibit 5 α Reductase-2. It reduced the concentration of DHT more than finasteride (94.7% vs. 70.8%). Dutasteride to 5 α The inhibitory effect of Reductase-1 was 60 times that of finasteride. The incidence rate of prostate cancer was 50% lower than that of placebo group 27 months after taking the drug.
Dutasteride can be used to treat moderate and severe symptoms of benign prostatic hyperplasia (BPH). For patients with moderate or severe symptoms of benign prostatic hyperplasia, * reduce the risk of acute urinary retention (AUR) and surgery.
Dutasteride can inhibit both type I and type II 5 α Reductase, through this dual inhibition mechanism, can reduce the prostate volume rapidly and continuously. * Chemicalbook significantly improves the symptoms of lower urinary tract, reduces the risk of acute urinary retention and related prostate surgery, and benefits patients, especially the majority of patients with moderate to severe BPH.