Sulbactam is β- Lactamase inhibitor, chemical property, white crystalline solid, soluble in water.
It has strong irreversible inhibition on penicillinase and cephalosporinase. Chang and others β- The combination of lactam antibiotics has obvious synergistic effect
β- Lactamase inhibitor has strong irreversible inhibitory effect on penicillinase and cephalosporinase. Its antibacterial activity is very weak, so it is rarely used alone and often combined with others β- The combination of lactam antibiotics has obvious synergistic effect and is effective for most drug-resistant bacteria. Sulperzon, a compound preparation prepared with cefoperazone, was used to treat the infection of drug-resistant bacteria; And ampicillin to form a composite preparation. For synthesis of sulbactam sodium