Enticavir

Entecavir is a new generation of guanine nucleoside analogues used in the treatment of hepatitis B virus infection. It is mainly used to treat adult chronic hepatitis B with active viral replication and continuous elevated serum aminotransferase, or liver histologically active disease. It is the fastest and strongest nucleoside analogues with the lowest mutation rate.

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1000

CAS:

142217-69-4

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Product description

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product INTRO

Antiviral drugs for patients with chronic hepatitis B include two categories: Interferons and nucleoside (acid) analogues. At present, five oral nucleoside (acid) analogues are listed in China: entecavir (ETV), tenofovir dipivoxil (TDF), telbivudine (LDT), adefovir dipivoxil (ADV) and lamivudine (LAM). Entecavir is one of the first-line antiviral drugs recommended by the World Health Organization and national guidelines for patients with chronic hepatitis B.

FUNCTION

It is used to treat chronic adult hepatitis B with active virus replication, continuous increase of serum alanine aminotransferase (ALT) or active liver histology.

APPLICATION

1. Entecavir is not a substrate, inhibitor or inducer of cytochrome P450 enzyme system and does not inhibit any major human cytochrome P450 enzymes (1A2, 2C9, 2c19, 2d6, 3A4, 2b6 and 2E1).

2. Entecavir is mainly cleared through the kidney. While taking drugs that reduce renal function or competitive secretion through active glomerulus, taking entecavir may increase the blood concentration of these two drugs.

Keyword:

enticavir

entecavir

and

the

active

drugs

hepatitis

chronic

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