Felodipine is a nifedipine calcium antagonist. It is characterized by selective dilation of small arteries and dilation of coronary and peripheral vessels; At high concentration, calmodulin is inhibited, which interferes with the utilization of intracellular calcium. It can increase the blood flow of coronary sinus, reduce systemic and coronary vascular resistance, and reduce blood pressure. There was no negative inotropic effect on myocardium at the therapeutic dose. Long term application is conducive to the reversal of left ventricular hypertrophy.
It is a selective calcium antagonist. It mainly inhibits the influx of extracellular calcium in arteriolar smooth muscle cells and selectively dilates arterioles. It has no effect on veins and does not cause postural hypotension; It also had no significant inhibitory effect on myocardium. While reducing the chemical book of renal vascular resistance, this product does not affect the glomerular filtration rate and creatinine clearance rate, has no change or even slightly increased renal blood flow, and has the effects of promoting urinary sodium excretion and diuresis. This product can increase output and cardiac index, significantly reduce afterload, and has no significant effect on cardiac systolic function, preload and heart rate.
1. Calcium antagonist. For mild, moderate or severe hypertension, heart failure and ischemic heart disease.
2. It is used to treat hypertension, cardiac gum pain, congestive heart failure and is effective for all degrees of hypertension.
3. It is used to treat hypertension, ischemic heart disease, heart failure and other diseases.